This is a workhorse immunologic assay useful in the approach to a variety of chronic diseases. The test measures serum IgG and IgA antibodies to gliadin (GA)and serum IgA antibodies to tissue transglutamate (tTG). Type IV reactions are cell-mediated. Killer T-cells become cytotoxic when activated by an antigen. These cytotoxic cells are capable of killing bacteria, viruses, tumor cells, or other target cells. This reaction is involved in very severe food reactions to the gliadin protein in grains. An overload of IgG antibody-allergen complexes can cause damage to the gut mucosal lining and cause protein wasting in conditions such as Celiac disease, Ulcerative Colitis, Crohn’s disease, and Leaky Gut. The leaky gut then allows more antibody-allergen complexes to escape into tissues, which provokes more food allergies.
It has been speculated that historically and evolutionarily, the introduction of grains as staple food sources was a consequence of the rice of agrarian culture, a dramatic departure from the preceding hunting, gathering, and foraging cultures. The human body has not yet fully adapted to the change.
Gluten ( a protein found in wheat and other grains) is well known for its link to celiac disease.
Gliadin ( a protein sub-fraction of gluten,. The modification of gliadin by tissue translugtaminase, a common cross-linking enzyme, has been shown to be responsible for muc of the antigenicity of gluten.
Meridian Valley Laboratory’s Gluten Sensitivity Panel is a cost-effective, sensitive, and specific assay for the diagnosis of celiac disease and a useful tool in the work up of patients with a wide variety of other chronic conditions.
- Celiac Disease
- Diabetes Mellitus (Type I)
- Hepatic Disease
- Neurological Disorders
- Rheumatoid Arthitis
- Thyroiditis (Auto-immune)
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