Meridian Valley Lab is proud to offer a cutting edge laboratory test for the evaluation of prostate cancer risk.
Testosterone gives rise to important downstream metabolites. While 5α-dihydrotestosterone (5α-DHT) is well known for its role in exacerbating prostate problems, there is another metabolite that is emerging as a key influencer on prostate health. That metabolite is known as 5α-Androstane-3β, 17β-diol (3β-Adiol).
3β-Adiol is created from 5α-DHT, catalyzed by the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD). 3β-Adiol does not bind to androgen receptors; rather 3β-Adiol is a potent stimulator of Estrogen Receptor-β (ERβ). In the prostate, 3β-Adiol’s stimulation of ERβ prevents excess cell proliferation and stimulates apoptosis and re-differentiation. ERβ stimulation via compounded 3β-Adiol is an emerging therapy in the treatment of aggressive prostate cancer.
3β-Adiol is commonly deficient in men taking 5α-reductase inhibiting drugs for the treatment of BPH or male pattern hair loss. Click here for an in-depth discussion on the concerns of 5α-reductase over-inhibition.
Who should get tested?
- Individuals with a family history of prostate cancer or anyone concerned about their risk for prostate problems
- Individuals taking pharmaceutical 5α-reductase inhibitors such as Proscar or Avodart
- Individuals taking natural 5α-reductase inhibitors such as Saw Palmetto or higher dose zinc therapy
- Any man taking supplemental testosterone
|Test Code||Profile Name||Instructions|
|4417||Testosterone Metabolites (Te DHT Adiol 3a & 3b Adiol)||Instructions|