Clinical Significance of 5a-Reductase Activity
5a-Reductase (5AR) is the enzyme that catalyzes the conversion of (among others): Testosterone → 5a-DHT Androstenedione→ androsterone Cortisol → allo-tetrahydrocortisol Measuring the levels of the above hormones and metabolites in urine and blood, we can quantify overall 5AR activity. In urine, two ratios are commonly used to assess 5AR activity: Androsterone : Etiocholanone Allo-tetrahydrocortisol :